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Home / Archives for drug resistance

Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?

January 28, 2016 By Malaria.com Leave a Comment

Abstract High-dose chemotherapy has long been advocated as a means of controlling drug resistance in infectious diseases but recent empirical studies have begun to challenge this view. We develop a very general framework for modeling and understanding resistance emergence based on principles from evolutionary biology. We use this framework to show how high-dose chemotherapy engenders opposing … [Read more...]

Filed Under: Malaria Research Tagged With: Computational Biology, drug resistance

Malaria in Pakistan

September 10, 2012 By Malaria Q&A Leave a Comment

QUESTION 4 years ago I traveled to FATA Pakistan and in every year in the month of August I caught malaria. Last few days I feel much Headache and fever in the evening and go to doctor. He diagnosed malarial parasites in blood and has advised me take tab artem ds 2 BD for three days after complete the course I feel same headache fever with shivering. Please recommend something. ANSWER I … [Read more...]

Filed Under: Malaria Q&A Tagged With: Artemisinin, drug resistance, recrudescence, relapse, side effects, treatment, World Health Organization

Antimalarial Drugs During pPregnancy

August 6, 2012 By Malaria Q&A Leave a Comment

QUESTION What is the safest antimalarial drug to be used by a pregnant woman in her second trimester? ANSWER With regards to treating malaria, intravenous artesunate (or quinine, if artesunate is not available) should be used for the treatment of severe/complicated Plasmodium falciparum malaria. Signs of severe and/or complicated malaria include impaired consciousness, organ failure, … [Read more...]

Filed Under: Malaria Q&A Tagged With: anti-malarial treatment, Artesunate, Chemoprophylaxis, Chloroquine, clindamycin, complicated malaria, drug resistance, IV, malaria in pregnancy, Mefloquine, Plasmodium Falciparum, Plasmodium Knowlesi, Plasmodium malariae, Plasmodium Ovale, Plasmodium Vivax, primagravidae, Quinine, severe malaria

How is Malaria Prevented?

July 21, 2012 By Malaria Q&A Leave a Comment

QUESTION What are the methods to prevent malaria? ANSWER Malaria prevention consists of a combination of mosquito avoidance measures and chemoprophylaxis. Although very efficacious, none of the recommended interventions are 100% effective. Mosquito Avoidance Measures Because of the nocturnal feeding habits of Anopheles mosquitoes, malaria transmission occurs primarily between dusk … [Read more...]

Filed Under: Malaria Q&A Tagged With: Chemoprophylaxis, Chloroquine, drug resistance, Fansidar, indoor residual spraying, insect repellent, long-lasting insecticide treated bednets, Malaria Prevention, Mefloquine, mosquito prevention, Plasmodium Ovale, Plasmodium Vivax, Primaquine, sulfadoxine-pyramethamine, travel medicine

How is Malaria Treated

June 12, 2012 By Malaria Q&A Leave a Comment

QUESTION how is malaria treated? ANSWER Malaria can be a severe, potentially fatal disease (especially when caused by Plasmodium falciparum) and treatment should be initiated as soon as possible. Patients who have severe P. falciparum malaria or who cannot take oral medications should be given the treatment by continuous intravenous infusion. Most drugs used in treatment are active … [Read more...]

Filed Under: Malaria Q&A Tagged With: artemisin, Artemisinin-based Combination Therapies, atovaquine-proguanil, Chloroquine, chloroquine resistance, Coartem, combination therapies, Doxycycline, drug resistance, Lariam, Malaria Treatment, Malarone, Mefloquine, Primaquine, Quinine

Dormant Malaria

June 10, 2012 By Malaria Q&A Leave a Comment

QUESTION I was bitten by mosquitoes many years ago and I was wondering can the symptoms lie dormant for as long as 40 years? The reason I am asking is that every summer I am ill with several of these symptoms. I do not have a good immune system. ANSWER There are a couple of types of malaria, namely Plasmodium vivax and Plasmodium ovale, which can lie dormant for many years, and often … [Read more...]

Filed Under: Malaria Q&A Tagged With: dormant forms, drug resistance, G6DP deficiency, Malaria Symptoms, Malaria Treatment, mosquito, Primaquine, relapse

Drug-Resistant Malaria Threatens Effort to Control Disease

April 11, 2012 By Malaria.com Leave a Comment

A team of researchers from the United States and Thailand says the growing number of cases of drug-resistant malaria being reported in Thailand and neighboring countries threatens the worldwide campaign to control and eliminate the mosquito-borne disease. The malaria parasite in the region is becoming resistant to the first-line malaria therapy - artemisinin combination treatment - and experts say … [Read more...]

Filed Under: Malaria News Tagged With: artemisinin combination treatment, drug resistance, Drug Resistant Malaria

Malaria Prevention

April 7, 2012 By Malaria Q&A Leave a Comment

QUESTION What are the ways in which you can prevent yourself from being infected with malaria? ANSWER Malaria prevention consists of a combination of mosquito avoidance measures (since malaria is transmitted by infected mosquitoes) and chemoprophylaxis (medication to prevent the establishment of malaria in your body, if you do get bitten). Although very efficacious, none of the … [Read more...]

Filed Under: Malaria Q&A Tagged With: Chemoprophylaxis, Chloroquine, Counterfeit Drugs, DEET, drug resistance, Fansidar, insect repellant, long-lasting insecticide treated bednets, long-sleeved clothing, malaria medication, Malaria transmission, Mefloquine, mosquito, Permethrin, Plasmodium Falciparum, Plasmodium Ovale, Plasmodium Vivax, Presumptive antirelapse therapy, prophylaxis, protective measures, screens, sulfadoxine-pyrimethamine, travel medicine, vector control

Resistance to Malaria Treatments Seriously Compromises Efforts to Eliminate Malaria

April 5, 2012 By Malaria.com Leave a Comment

Scientists have found new evidence that resistance to the front-line treatments for malaria is increasing.They have confirmed that resistant strains of the malaria parasite on the border between Thailand and Burma, 500 miles (800km) away from previous sites.Researchers say that the rise of resistance means the effort to eliminate malaria is "seriously compromised".The details have been … [Read more...]

Filed Under: Malaria News Tagged With: drug resistance

Antimalarial Drug Therapeutic Life

December 5, 2011 By Malaria Q&A 1 Comment

QUESTION Why do some antimalarial drugs have long therapeutic life while others have short therapeutic lives? ANSWER Different anti-malarial drugs target slightly different aspects of the malaria Plasmodium parasite, and so are made with different chemical structures. The differences in therapeutic life across different malaria drugs has to do with the specific pharmacokinetic … [Read more...]

Filed Under: Malaria Q&A Tagged With: 4-aminoquinoline, amodioquine, anti-malarial drugs, Atovaquone, biological half life, Chloroquine, dihydrofolate reductase inhibitor, drug resistance, Lariam, Malaria Treatment, Malarone, Mefloquine, Plasmodium, proguanil, quinoline methanol

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The WorldWide Antimalarial Resistance Network (WWARN) generates innovative resources and reliable evidence to inform the malaria community on the factors affecting the efficacy of antimalarial medicines. Learn more…

  • Fighting Malaria Requires Protecting the Effectiveness of Antimalarial Medicines
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