• About Us
  • Board of Advisors
  • Contact

MALARIA.com

A Malaria Information and Community Portal

  • Home
  • Malaria Overview
  • Malaria Research
  • News
  • Videos
  • Blogs
  • Malaria Q&A
  • Events
  • Jobs
Home / Archives for Malaria Research

KSHV Oral Shedding and Plasma Viremia Result in Significant Changes in the Extracellular Tumorigenic miRNA Expression Profile in Individuals Infected with the Malaria Parasite

February 9, 2018 By Malaria.com Leave a Comment

Kaposi's sarcoma herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma (KS). Both KSHV and HIV infections are endemic in Uganda, where KS is among the most common cancers in HIV-infected individuals. Recent studies examined the use of small RNAs as biomarkers of disease, including microRNAs (miRNAs), with viral and tumor-derived miRNAs being detected in exosomes from individuals with … [Read more...]

Filed Under: Malaria Research Tagged With: Corey Casper, HIV, KSHV, Michael R. Dyen, Minako Ikoma, miRNA, Plasmodium Falciparum, PLoS One, Qing Zhang, Ryan Basom, Serge Barcy, Soren Gantt, Timothy M. Rose, Uganda, Yuko Ogata

Tools and Strategies for Malaria Control and Elimination: What Do We Need to Achieve a Grand Convergence in Malaria?

March 2, 2016 By Malaria.com Leave a Comment

Abstract Progress made in malaria control during the past decade has prompted increasing global dialogue on malaria elimination and eradication. The product development pipeline for malaria has never been stronger, with promising new tools to detect, treat, and prevent malaria, including innovative diagnostics, medicines, vaccines, vector control products, and improved mechanisms for surveillance … [Read more...]

Filed Under: Malaria Research Tagged With: Malaria Control

Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?

January 28, 2016 By Malaria.com Leave a Comment

Abstract High-dose chemotherapy has long been advocated as a means of controlling drug resistance in infectious diseases but recent empirical studies have begun to challenge this view. We develop a very general framework for modeling and understanding resistance emergence based on principles from evolutionary biology. We use this framework to show how high-dose chemotherapy engenders opposing … [Read more...]

Filed Under: Malaria Research Tagged With: Computational Biology, drug resistance

Targeting the Cell Stress Response of Plasmodium Falciparum to Overcome Artemisinin Resistance

April 22, 2015 By Malaria.com Leave a Comment

As recently published in PLOS Biology: Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that the prevalence of this resistance is increasing, are alarming. ART resistance has recently been linked to mutations in the K13 propeller protein. The researchers undertook … [Read more...]

Filed Under: Malaria Research Tagged With: artemisinin resistance, Cambodia

Challenges in Modelling Infectious DIsease Dynamics

April 16, 2015 By Malaria.com Leave a Comment

Malaria, HIV, and tuberculosis (TB) collectively account for several million deaths each year, with all three ranking among the top ten killers in low-income countries. Despite being caused by very different organisms, malaria, HIV, and TB present a suite of challenges for mathematical modellers that are particularly pronounced in these infections, but represent general problems in infectious … [Read more...]

Filed Under: Malaria Research

Landscape Ecology and Epidemiology of Malaria Associated with Rubber Plantations in Thailand: Integrated Approaches to Malaria Ecotoping

April 16, 2015 By Malaria.com Leave a Comment

The agricultural land use changes that are human-induced changes in agroforestry ecosystems and in physical environmental conditions contribute substantially to the potential risks for malaria transmission in receptive areas. Due to the pattern and extent of land use change, the risks or negatively ecosystemic outcomes are the results of the dynamics of malaria transmission, the susceptibility of … [Read more...]

Filed Under: Malaria Research

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria : Nature : Nature Publishing Group

April 15, 2015 By Malaria.com Leave a Comment

Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance to them raises risk of wiping out recent gains achieved in reducing worldwide malaria burden and threatens future malaria control and elimination on a global level. Genome-wide association studies (GWAS) have revealed parasite genetic loci associated with artemisinin resistance. However, there is no … [Read more...]

Filed Under: Malaria Research

Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle

April 2, 2015 By Malaria.com Leave a Comment

New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing and new antimalarials. Herein, we describe 11 genetic knockout (KO) lines that delete six of the eight mitochondrial tricarboxylic acid (TCA) cycle enzymes. Although all TCA KOs grew normally in asexual blood … [Read more...]

Filed Under: Malaria Research

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

February 21, 2015 By Malaria.com Leave a Comment

Emergence of artemisinin resistance in southeast Asia poses a serious threat to the global control of Plasmodium falciparum malaria. Discovery of the K13 marker has transformed approaches to the monitoring of artemisinin resistance, allowing introduction of molecular surveillance in remote areas through analysis of DNA. We aimed to assess the spread of artemisinin-resistant P falciparum in Myanmar … [Read more...]

Filed Under: Malaria Research Tagged With: artemisinin resistance, Myanmar, The Lancet

A Country on the Verge of Malaria Elimination – The Kingdom of Saudi Arabia

September 24, 2014 By Malaria.com Leave a Comment

Significant headway has been made in the global fight against malaria in the past decade and as more countries enter the elimination phase, attention is now focused on identifying effective strategies to shrink the malaria map. Saudi Arabia experienced an outbreak of malaria in 1998, but is now on the brink of malaria elimination, with just 82 autochthonous cases reported in 2012. A review of … [Read more...]

Filed Under: Malaria Research Tagged With: Malaria Eradication, Saudi Arabia

Next Page »

Stay Informed

WWARN Corner

About WWARN

The WorldWide Antimalarial Resistance Network (WWARN) generates innovative resources and reliable evidence to inform the malaria community on the factors affecting the efficacy of antimalarial medicines. Learn more…

  • Fighting Malaria Requires Protecting the Effectiveness of Antimalarial Medicines
  • Data Sharing at IDDO
  • Evidence to inform equitable dosing in very young and malnourished children

More WWARN Stories...

  • Home
  • Malaria Overview
  • Malaria Research
  • News
  • Videos
  • Blogs
  • Malaria Q&A
  • Events
  • Jobs
  • About Us
  • Board of Advisors
  • Contact

Copyright © 2023 Malaria.com · Log in