"2014 in Review" Issue


Malaria Drug Resistance Spreading to Wider Geographic Area

The world’s best drug for treating malaria, a medicine that is the key to saving millions of lives in Africa and beyond, is losing its efficacy in a much larger swath of territory than was previously known, according to research that was released Friday.The study, in The Lancet Infectious Diseases, a medical journal, raises the […]

Public Review of the 2nd Generation Global Malaria Action Plan 2016-2030

Statement from David Brandling Bennett, Bill & Melinda Gates Foundation and Bernard Nahlen, U.S Presidents Malaria Initiative; Co-Chairs of the GMAP2 Task Force: “After months of extensive enquiry and a world-wide consultation which targeted constituencies and stakeholders in all sectors of society, we are delighted to invite the broader development community to review the penultimate […]

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Claire Standley, Editor

World Malaria Day 2014 – How Best to Invest in Malaria Prevention and Control

Each year, April 25 provides an opportunity to reflect on the current status of the fight against malaria. We are in the middle year of the World Malaria Day theme of “Invest in the Future. Defeat Malaria,” which is set to last until 2015. Funding for malaria control and prevention, as with all international public health endeavors, has always been perceived as a critical issue, but there is a refreshing diversity to the ways in which it is being discussed this World Malaria Day.

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A Country on the Verge of Malaria Elimination – The Kingdom of Saudi Arabia

Significant headway has been made in the global fight against malaria in the past decade and as more countries enter the elimination phase, attention is now focused on identifying effective strategies to shrink the malaria map. Saudi Arabia experienced an outbreak of malaria in 1998, but is now on the brink of malaria elimination, with […]

IgG1 and IgG4 Antibody Responses to the Anopheles gambiae Salivary Protein gSG6

Human antibody response to the Anopheles gambiae salivary protein gSG6 has recently emerged as a potentially useful tool for malaria epidemiological studies and for the evaluation of vector control interventions. However, the current understanding of the host immune response to mosquito salivary proteins and of the possible crosstalk with early response to Plasmodium parasites is still very limited.

Targeting NAD+ Metabolism in the Human Malaria Parasite Plasmodium falciparum

Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite utilized as a redox cofactor and enzyme substrate in numerous cellular processes. Elevated NAD+ levels have been observed in red blood cells infected with the malaria parasite Plasmodium falciparum, but little is known regarding how the parasite generates NAD+. In this study, researchers employed a mass spectrometry-based metabolomic approach to confirm that P. falciparum lacks the ability to synthesize NAD+ de novo and is reliant on the uptake of exogenous niacin.

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