Malaria Diagnostics

Introducing a New Look for, and Welcome to Our Diagnostics Issue!

This week we are launching a new look for, and are now also publishing a quarterly online “issue” devoted to a specific topic related to malaria. We hope that these focused issues will allow our readers to delve more deeply into the challenges and opportunities associated with malaria control, and also provide multiple perspectives—from all around the world—under a shared theme. See the articles below from our first “issue” devoted to a supremely important topic in malaria control: diagnostics. Learn more… Diagnostics Issue


Regular Preventive Malaria Treatment Reduces Risk in Children

Protecting young children from malaria in countries where the mosquito-borne illness is endemic can include preventive drug treatment during the rainy season, when most infections occur.  Now, researchers report that delivering an anti-malaria drug monthly, all year long, dramatically reduces the risk of this potentially lethal disease in infants and toddlers. Ninety percent of the […]

GlaxoSmithKline Applies for Approval of RTS,S Malaria Vaccine

A “pretty good” malaria vaccine is on track to be the first to market. It only prevents infection about one-quarter to one-half the time, so it’s not as good as most vaccines. But for a disease like malaria, which kills 600,000 people a year, “pretty good” may be good enough. GlaxoSmithKline has applied for regulatory approval for its […]

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Claire Standley, Editor

World Malaria Day 2014 – How Best to Invest in Malaria Prevention and Control

Each year, April 25 provides an opportunity to reflect on the current status of the fight against malaria. We are in the middle year of the World Malaria Day theme of “Invest in the Future. Defeat Malaria,” which is set to last until 2015. Funding for malaria control and prevention, as with all international public health endeavors, has always been perceived as a critical issue, but there is a refreshing diversity to the ways in which it is being discussed this World Malaria Day.

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IgG1 and IgG4 Antibody Responses to the Anopheles gambiae Salivary Protein gSG6

Human antibody response to the Anopheles gambiae salivary protein gSG6 has recently emerged as a potentially useful tool for malaria epidemiological studies and for the evaluation of vector control interventions. However, the current understanding of the host immune response to mosquito salivary proteins and of the possible crosstalk with early response to Plasmodium parasites is […]

Targeting NAD+ Metabolism in the Human Malaria Parasite Plasmodium falciparum

Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite utilized as a redox cofactor and enzyme substrate in numerous cellular processes. Elevated NAD+ levels have been observed in red blood cells infected with the malaria parasite Plasmodium falciparum, but little is known regarding how the parasite generates NAD+. Here, we employed a mass spectrometry-based metabolomic approach […]

Diagnostic Testing of Pediatric Fevers: Meta-Analysis of 13 National Surveys Assessing Influences of Malaria Endemicity and Source of Care on Test Uptake for Febrile Children under Five Years

In 2010, the World Health Organization revised guidelines to recommend diagnosis of all suspected malaria cases prior to treatment. There has been no systematic assessment of malaria test uptake for pediatric fevers at the population level as countries start implementing guidelines. We examined test use for pediatric fevers in relation to malaria endemicity and treatment-seeking […]

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