Does malaria spread from a person to another?


Can malaria spread from one person to another?


Usually, no. In most cases, the malaria parasite has to first pass from a human host into a mosquito as the mosquito takes a blood meal, and then from the mosquito into another human via the mosquito’s saliva. This severely limits the amount of person-to-person transmission that exists. In fact, the only mechanisms for direct transmission between humans are when malaria parasites are passed between a mother and her unborn child via the placenta (congenital transmission) and through unscreened blood transfusions.

Congenital malaria is the more common type of human-to-human transmission; across various surveys of newborns in West Africa, between 8-24% were found to be infected with malaria parasites.

All four main species of human malaria (P. falciparum, P. vivax, P. ovale and P. malariae) have been implicated in congenital transmission. Infection with malaria during pregnancy not only puts the mother at greater risk of severe disease episodes (probably through reduced immunocompetence during pregnancy) but may also negatively impact the baby; although in endemic areas it is rare for babies to be symptomatic for malaria when acquired congenitally, even if they have parasitaemia, they have been shown to have a higher mortality rate than non-infected newborns. In non-endemic areas, babies with congenital malaria often display symptoms, which usually manifest themselves between 2 and 8 weeks after birth. Both quinine and artemisinin-based therapies have been successfully used to treat congenital malaria.

Malaria infection as a result of blood transfusion was first identified in 1911 and is one of the most common illness transmitted via transfusion, although the risk of being infected, particularly in non-endemic countries, is very low.

As it is difficult to screen blood directly for malaria infection, a number of standards have been put in place by blood-collection services to reduce the risk of obtaining blood containing malaria parasites. For example, in many places, you will not be allowed to donate whole blood if you have visited an endemic malarial region in the last three months, nor should you donate if you have previously had malaria unless you have been symptom-free for at least three years.

Due to the longevity of Plasmodium malariae in the blood, you are unlikely to be able to donate blood if you have ever been confirmed as positive for P. malariae. Serological screening of blood for malaria antibodies has recently been shown to be a sensitive method for testing for malaria in blood, although it is expensive and therefore not cost-effective for screening every sample, especially in non-endemic countries. However, it can be effective and efficient to avoid wastage when employed together with a travel-based questionnaire to ascertain donors who are high-risk for malaria.

It is worth mentioning that transmission of malaria via plasma only is very uncommon, and so frequent travellers or residents in malarial areas, who may be denied the right to donate whole blood, should ask about the possibility of donating plasma instead.