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Home / Archives for APL1

Researchers Discover Proteins in Mosquitoes that Help Fight Malaria Infection

June 6, 2012 By Malaria.com Leave a Comment

Researchers have discovered the function of a series proteins within the mosquito that transduce a signal that enables the mosquito to fight off infection from the parasite that causes malaria in humans. Together, these proteins are known as immune deficiency (Imd) pathway signal transducing factors, are analogous to an electrical circuit. As each factor is switched on or off it triggers or … [Read more...]

Filed Under: Malaria News Tagged With: Ana C. Bahia, Anopheles gambiae, APL1, Caspar, FBN9, George Dimopoulos, Immune Deficiency (Imd) Pathway Signal Transducing Factors, Jayme A. Souza-Neo, Jessica Shiao, Johns Hopkins Malaria Research Institute, Lindsey S. Garver, Rel2, Suchismita Das, TEP1, Yuemei Dong

APL1 Malaria Resistance Genes of Anopheles Gambiae

March 8, 2011 By Malaria.com Leave a Comment

Immune defense genes are sometimes highly variable in host populations, reflecting selective pressure to combat diverse pathogens. In other instances, where there are only a few dominant pathogens, natural selection may favor only one or a few defense alleles. Here, we show that both adaptive strategies can occur in the same genes under different circumstances. We examined diversity in the … [Read more...]

Filed Under: Malaria Research Tagged With: A. gambiae, Anopheles gambiae, APL1, Malaria Resistance, Susan M. Rottschaefer

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