Abstract Progress made in malaria control during the past decade has prompted increasing global dialogue on malaria elimination and eradication. The product development pipeline for malaria has never been stronger, with promising new tools to detect, treat, and prevent malaria, including innovative diagnostics, medicines, vaccines, vector control products, and improved mechanisms for surveillance … [Read more...]
Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?
Abstract High-dose chemotherapy has long been advocated as a means of controlling drug resistance in infectious diseases but recent empirical studies have begun to challenge this view. We develop a very general framework for modeling and understanding resistance emergence based on principles from evolutionary biology. We use this framework to show how high-dose chemotherapy engenders opposing … [Read more...]
Eradicate Malaria, Says Obama During State of Union Speech
Two days before delivering his last State of the Union address, President Obama called one of his top advisers into the Oval Office and said he had decided to add a major pledge to the speech that his team had neither discussed nor vetted: to rid the world of malaria... The result was two sentences in his State of the Union address about how, in part through American commitment, the world could … [Read more...]
Notes from the Field: Q&A with Jackline
Jackline is a Ugandan medical doctor and maternal health specialist. Malaria.com caught up with Jackline to ask her a few questions about her work, and specifically her observations on the impacts of malaria on pregnant women. What is a typical day like for you when working in the field? A typical day involves waking up at 6am, preparing for the day and by 8am I am in the ward. First I … [Read more...]
Joel Tarning Awarded the Giorgio Segré Prize for Pharmaceutical Research
The European Federation for Pharmaceutical Sciences (EUFEPS) has awarded the Giorgio Segré Prize to Prof Joel Tarning for his scientific research work on the pharmacokinetic and pharmacodynamic properties of antimalarial drugs in vulnerable populations, such as pregnant women and young children. … [Read more...]
World Health Organization (WHO) Strategy Aims to Eliminate Malaria in 35 New Countries by 2030
WHO Member States today agreed a new global malaria strategy for 2016-2030 and approved the Organization's proposed program budget for 2016-2017. The strategy aims to reduce the global disease burden by 40% by 2020, and by at least 90% by 2030. It also aims to eliminate malaria in at least 35 new countries by 2030. … [Read more...]
RTS,S Malaria Vaccine Phase III Trial Results Show Promise, Though Diminished Effectiveness Over Time
Final results from a large-scale Phase III trial of the RTS,S malaria vaccine candidate, including the impact of a booster dose, published today in The Lancet, show that the vaccine candidate helped protect children and infants from clinical malaria for at least three years after first vaccination. … [Read more...]
A World Without Malaria
How We Could Have A World Without Malaria [Infographic] by the team at Work The World … [Read more...]
Targeting the Cell Stress Response of Plasmodium Falciparum to Overcome Artemisinin Resistance
As recently published in PLOS Biology: Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that the prevalence of this resistance is increasing, are alarming. ART resistance has recently been linked to mutations in the K13 propeller protein. The researchers undertook … [Read more...]
The President’s Malaria Initiative: Ninth Annual Report to Congress 2015
April 25, 2015, marks World Malaria Day – a day to celebrate the gains made in the fight against malaria. Each year, this day highlights global efforts to control malaria and mobilizes action to combat the disease. On this occasion, the President’s Malaria Initiative (PMI), led by the U.S. Agency for International Development (USAID) and implemented together with the U.S. Centers for Disease … [Read more...]