To optimize the fluid status of adult patients with severe malaria, World Health Organization (WHO) guidelines recommend the insertion of a central venous catheter (CVC) and a target central venous pressure (CVP) of 0-5 cmH2O. However there are few data from clinical trials to support this recommendation. Methods Twenty-eight adult Indian and Bangladeshi patients admitted to the intensive care … [Read more...]
Central Venous Catheter Use in Severe Malaria: Time to Reconsider the World Health Organization Guidelines?
November 14, 2011 By Leave a Comment
REVIEW: The Use of Intermittent Preventive Treatment in Pregnancy to Protect Against Malaria Infection
June 24, 2011 By Leave a Comment
Review of Le Port A, et al. (2011), ‘Prevention of Malaria during Pregnancy: Assessing the Effect of the Distribution of IPTp Through the National Policy in Benin’, American Journal of Tropical Medicine and Hygiene, Vol 84 (Issue 2): pp 270-275 … [Read more...]
Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria
May 19, 2011 By 2 Comments
Human genetics and immune responses are considered to critically influence the outcome of malaria infections including life-threatening syndromes caused by Plasmodium falciparum. An important role in immune regulation is assigned to the apoptosis-signaling cell surface receptor CD95 (Fas, APO-1), encoded by the gene FAS. Here, a candidate-gene association study including variant discovery … [Read more...]
Of Macaques and Men
March 12, 2011 By 2 Comments
Plasmodium knowlesi —a new challenge in the Roll Back Malaria Program? Mention of malaria often conjures images of infants hospitalized in Africa. Although most deaths from malaria are children under 5 in sub-Saharan Africa, there are many different types of malaria that put over half of the world’s population at risk in subtropical and tropical regions worldwide. There have … [Read more...]
APL1 Malaria Resistance Genes of Anopheles Gambiae
March 8, 2011 By Leave a Comment
Immune defense genes are sometimes highly variable in host populations, reflecting selective pressure to combat diverse pathogens. In other instances, where there are only a few dominant pathogens, natural selection may favor only one or a few defense alleles. Here, we show that both adaptive strategies can occur in the same genes under different circumstances. We examined diversity in the … [Read more...]
Malaria Control with Transgenic Mosquitoes
February 22, 2011 By Leave a Comment
Malaria has been eliminated from a large part of the world. By the mid-twentieth century both North America and Europe were free of the disease, although both had suffered greatly during the prior century [1,2]. While a variety of means were used to achieve this eradication, the most important are thought to be reducing the number of breeding sites for malaria vectors and improving residential … [Read more...]
Priorities in Malaria Research
February 22, 2011 By Leave a Comment
Malaria remains a challenging prospect for researchers and health workers, but there is encouraging news to report. Malaria research, after many years on the back burner, has risen dramatically up the priority list of donors and policy makers. Much of the credit for this turnaround must go to the Multilateral Initiative on Malaria (MIM; http://www.mim.su.se). MIM's achievements in the … [Read more...]
Use of Integrated Malaria Management Reduces Malaria in Kenya
February 22, 2011 By Leave a Comment
During an entomological survey in preparation for malaria control interventions in Mwea division, the number of malaria cases at the Kimbimbi sub-district hospital was in a steady decline. The underlying factors for this reduction were unknown and needed to be identified before any malaria intervention tools were deployed in the area. We therefore set out to investigate the potential factors … [Read more...]
A Research Agenda for Malaria Eradication: Vector Control
January 25, 2011 By 2 Comments
Abstract: Different challenges are presented by the variety of malaria transmission environments present in the world today. In each setting, improved control for reduction of morbidity is a necessary first step towards the long-range goal of malaria eradication and a priority for regions where the disease burden is high. For many geographic areas where transmission rates are low to … [Read more...]
A Research Agenda for Malaria Eradication: Drugs
January 25, 2011 By Leave a Comment
Abstract: Antimalarial drugs will be essential tools at all stages of malaria elimination along the path towards eradication, including the early control or “attack” phase to drive down transmission and the later stages of maintaining interruption of transmission, preventing reintroduction of malaria, and eliminating the last residual foci of infection.Drugs will continue to be used to … [Read more...]
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