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Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria

May 19, 2011 By Malaria.com 2 Comments

Human genetics and immune responses are considered to critically influence the outcome of malaria infections including life-threatening syndromes caused by Plasmodium falciparum. An important role in immune regulation is assigned to the apoptosis-signaling cell surface receptor CD95 (Fas, APO-1), encoded by the gene FAS. Here, a candidate-gene association study including variant discovery … [Read more...]

Filed Under: Malaria Research Tagged With: Andreas Ziegler, APO-1, Bernhard Nocht Institute for Tropical Medicine, Carmen Dering, CD95, Christa Ehmen, Christian Timmann, Claudia Esser, Cosima C. Kretz, Daniel Ansong, Department of Molecular Medicine, Division of Immunogenetics- German Cancer Research Centre, German National Genome Research Network, Ghana, Infectious Disease Epidemiology Group - Bernhard Nocht Institute for Tropical Medicine, Institute of Medical Biometry and Statistics, Jennifer Evans, Jürgen May, Jürgen Sievertsen, Kathrin Schuldt, Malaria in Children, Peter H. Krammer, Rolf D. Horstmann, School of Medical Sciences - Kwame Nkrumah University of Science and Technology, Tsiri Agbenyega, University at Lübeck, University Hospital Schleswig-Holstein, Wibke Loag

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