Effective treatment of malaria patients requires definition of the antimalarial concentrations required in patients’ blood to assure that they are cured. The doses needed to achieve these concentrations in most patients have been determined, but many factors can influence the drug exposure actually achieved even when the same weight-based (mg/kg) dose is given to each patient. The studies that … [Read more...]
Large scale study on indicators of ACT efficacy in Africa
A new study from WWARN’s ACT Africa Baseline Study Group finds that current indicators of the efficacy of ACT based on persistence of parasites in the first 3 days after treatment may need some adjustment for African populations, due to the differences in immunity between African and Asian populations. Slow parasite clearance – the rate at which malaria parasites decline in the patient’s … [Read more...]