To optimize the fluid status of adult patients with severe malaria, World Health Organization (WHO) guidelines recommend the insertion of a central venous catheter (CVC) and a target central venous pressure (CVP) of 0-5 cmH2O. However there are few data from clinical trials to support this recommendation.
Twenty-eight adult Indian and Bangladeshi patients admitted to the intensive care unit with severe falciparum malaria were enrolled in the study. All patients had a CVC inserted and had regular CVP measurements recorded. The CVP measurements were compared with markers of disease severity, clinical endpoints and volumetric measures derived from transpulmonary thermodilution.
There was no correlation between the admission CVP and patient outcome (p = 0.67) or disease severity (p = 0.33). There was no correlation between the baseline CVP and the concomitant extravascular lung water (p = 0.62), global end diastolic volume (p = 0.88) or cardiac index (p = 0.44). There was no correlation between the baseline CVP and the likelihood of a patient being fluid responsive (p = 0.37). On the occasions when the CVP was in the WHO target range patients were usually hypovolaemic and often had pulmonary oedema by volumetric measures. Seven of 28 patients suffered a complication of the CVC insertion, although none were fatal.
The WHO recommendation for the routine insertion of a CVC, and the maintenance of a CVP of 0-5 cmH2O in adults with severe malaria, should be reconsidered.
Authors: Josh Hanson1,2*, Sophia WK Lam1,2, Sanjib Mohanty3, Shamshul Alam4, Md Mahtab U Hasan5, Sue J Lee2, Marcus J Schultz6, Prakaykaew Charunwatthana2, Sophie Cohen7, Ashraf Kabir8, Saroj Mishra3, Nicholas PJ Day2,9, Nicholas J White2,9 and Arjen M Dondorp2,9
* Corresponding author: Josh Hanson email@example.com
1 Department of Medicine, Cairns Base Hospital, Queensland, Australia
2 Mahidol Oxford Research Unit, Mahidol University, Bangkok, Thailand
3 Department of Medicine, Ispat General Hospital, Rourkela, India
4 Department of Intensive Care Medicine, Chittagong Medical College Hospital, Chittagong, Bangladesh
5 Department of Medicine, Chittagong Medical College Hospital, Chittagong, Bangladesh
6 Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
7 Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
8 Department of Anaesthetics, Cox’s Bazar Medical College, Cox’s Bazar, Bangladesh
9 Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
Citation: Malaria Journal 2011, 10:342 doi:10.1186/1475-2875-10-342
Copyright © by the authors, 2011. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.